| 2010 Division II Baseball All-Region Team | |||
| Player | Pos. | School | |
| First Team | |||
| Ronnie Stout | P | Monroe Community College | |
| Eric Francis | P | Mercyhurst North East College | |
| Eitan Maoz | C | Genesee Community College | |
| JP Frey | IF | Alfred State College | |
| John Polonious | IF | Genesee Community College | |
| Matthew Adamczyk | IF | Mercyhurst North East College | |
| Luis Diaz-Deleon | IF | Monroe Community College | |
| Chase Grissom | OF | Monroe Community College | |
| Matt Rensel | OF | Mercyhurst North East College | |
| Jake Dale | OF | Alfred State College | |
| Joe Polichetti | DH | Monroe Community College | |
|
Second Team |
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| Kevin Hughes | P | Genesee Community College | |
| Mark Ciccotti | P | Alfred State College | |
| Ronnie Kleinback | P | Genesee Community College | |
| Keith Geil | IF | Monroe Community College | |
| Kyle Barkley | IF | Alfred State College | |
| Kevin Daniels | IF | Genesee Community College | |
| Ryan Rovnak | IF | Mercyhurst North East College | |
| Christian Boghossian | IF | Monroe Community College | |
| Mitch Roy | OF | Genesee Community College | |
| Brian Zimmermann | OF | Alfred State College | |
| Sean Van Der Wal | OF | Mercyhurst North East College | |
| Doug Farley | OF | Mercyhurst North East College | |
| Joe Wallace | DH | Alfred State College | |